Anti Depressant Drugs Oral Medications Escitalopram Oxalate Tablets
Product : Escitalopram Oxalate Tablets
Specification : 5mg, 10mg, 20mg
Standard : BP, USP
Packing : 14’s/blister
Escitalopram tablets are film-coated, round tablets containing
escitalopram oxalate in strengths equivalent to 5 mg, 10 mg and 20
mg escitalopram base.
Escitalopram tablets should be administered once daily, in the
morning or evening, with or without food.
Indications and Usage
1.1 Major Depressive Disorder
Escitalopram tablets are indicated for the acute and maintenance
treatment of major depressive disorder in adults and in adolescents
12 to 17 years of age.
A major depressive episode (DSM-IV) implies a prominent and
relatively persistent (nearly every day for at least 2 weeks)
depressed or dysphoric mood that usually interferes with daily
functioning and includes at least five of the following nine
symptoms: depressed mood, loss of interest in usual activities,
significant change in weight and/or appetite, insomnia or
hypersomnia, psychomotor agitation or retardation, increased
fatigue, feelings of guilt or worthlessness, slowed thinking or
impaired concentration, a suicide attempt or suicidal ideation.
1.2 Generalized Anxiety Disorder
Escitalopram tablets are indicated for the acute treatment of
Generalized Anxiety Disorder (GAD) in adults.
Generalized Anxiety Disorder (DSM-IV) is characterized by excessive
anxiety and worry (apprehensive expectation) that is persistent for
at least 6 months and which the person finds difficult to control.
It must be associated with at least three of the following
symptoms: restlessness or feeling keyed up or on edge, being easily
fatigued, difficulty concentrating or mind going blank,
irritability, muscle tension and sleep disturbance.
Escitalopram is one of a class of antidepressants known as
selective serotonin reuptake inhibitors (SSRIs). It is used to
treat the depression associated with mood disorders. It is also
used on occassion in the treatment of body dysmorphic disorder and
anxiety. The antidepressant, antiobsessive-compulsive, and
antibulimic actions of escitalopram are presumed to be linked to
its inhibition of CNS neuronal uptake of serotonin. In vitro
studies show that escitalopram is a potent and selective inhibitor
of neuronal serotonin reuptake and has only very weak effects on
norepinephrine and dopamine neuronal reuptake. Escitalopram has no
significant affinity for adrenergic (alpha1, alpha2, beta),
cholinergic, GABA, dopaminergic, histaminergic, serotonergic
(5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of
such receptors has been hypothesized to be associated with various
anticholinergic, sedative, and cardiovascular effects for other
psychotropic drugs. The chronic administration of escitalopram was
found to downregulate brain norepinephrine receptors, as has been
observed with other drugs effective in the treatment of major
depressive disorder. Escitalopram does not inhibit monoamine
Mechanism of action
The antidepressant, antiobsessive-compulsive, and antibulimic
actions of escitalopram are presumed to be linked to its inhibition
of CNS neuronal uptake of serotonin. Escitalopram blocks the
reuptake of serotonin at the serotonin reuptake pump of the
neuronal membrane, enhancing the actions of serotonin on 5HT1A
autoreceptors. SSRIs bind with significantly less affinity to
histamine, acetylcholine, and norepinephrine receptors than
tricyclic antidepressant drugs.